Anna-Leena Sirén Selected Research

Factor XIIa (Coagulation Factor XIIa)

1/2017	Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa.
1/2016	Targeting coagulation factor XII as a novel therapeutic option in brain trauma.
2/2013	Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system.

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Anna-Leena Sirén Research Topics

Disease

6	Brain Injuries (Brain Injury) 05/2021 - 02/2006
5	Stroke (Strokes) 05/2015 - 08/2002
4	Wounds and Injuries (Trauma) 05/2021 - 09/2014
4	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2021 - 02/2013
4	Inflammation (Inflammations) 01/2017 - 08/2010
4	Hypoxia (Hypoxemia) 04/2006 - 07/2002
3	Cognitive Dysfunction 05/2021 - 12/2004
3	Brain Diseases (Brain Disorder) 10/2009 - 12/2004
2	Gliosis 01/2021 - 01/2016
2	Closed Head Injuries 01/2016 - 09/2012
2	Ischemia 01/2016 - 07/2002
2	Ischemic Stroke 05/2015 - 08/2002
2	Body Weight (Weight, Body) 07/2014 - 05/2009
2	Edema (Dropsy) 04/2012 - 08/2010
2	Atrophy 05/2009 - 02/2006
2	Schizophrenia (Dementia Praecox) 05/2009 - 12/2004
2	Anemia 12/2004 - 08/2004
1	Neuroinflammatory Diseases 05/2021
1	Thromboinflammation 05/2021
1	Brain Ischemia (Cerebral Ischemia) 05/2021
1	Medulloblastoma 01/2021
1	Neoplasms (Cancer) 01/2021
1	Pathologic Processes 01/2017
1	Brain Edema (Cerebral Edema) 01/2017
1	Thrombosis (Thrombus) 01/2016
1	Leukemia 03/2015
1	Contusions 09/2014
1	Demyelinating Diseases (Demyelinating Disease) 07/2014
1	Anhedonia 01/2014
1	Phototoxic Dermatitis (Phototoxicity) 07/2013
1	Hydrocephalus (Hydrocephaly) 09/2012
1	Stiff-Person Syndrome (Stiff Man Syndrome) 11/2010
1	Spasm (Spasms) 11/2010
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2010
1	Chronic Progressive Multiple Sclerosis 10/2007
1	Disease Progression 11/2006
1	Spinal Cord Injuries (Spinal Cord Injury) 10/2005
1	Cerebral Hemorrhage 10/2004

Drug/Important Bio-Agent (IBA)

8	Erythropoietin FDA Link 05/2009 - 08/2002
4	Factor XII (Hageman Factor)IBA 05/2021 - 01/2014
4	KininsIBA 01/2017 - 08/2010
4	Proteins (Proteins, Gene)FDA Link 01/2017 - 12/2004
3	Pharmaceutical PreparationsIBA 01/2021 - 08/2002
3	Factor XIIa (Coagulation Factor XIIa)IBA 01/2017 - 02/2013
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2009 - 02/2006
2	EnzymesIBA 01/2017 - 05/2009
2	AutoantibodiesIBA 05/2015 - 11/2010
2	Plasma KallikreinIBA 01/2014 - 02/2013
2	Bradykinin Receptors (Bradykinin Receptor)IBA 09/2012 - 08/2010
2	MelatoninIBA 11/2006 - 10/2002
1	Interleukin-1 (Interleukin 1)IBA 05/2021
1	Toll-Like Receptor 4IBA 05/2021
1	Metalloproteases (Metalloproteinases)IBA 05/2021
1	HMGB1 Protein (HMG1)IBA 05/2021
1	CytokinesIBA 05/2021
1	CorticosteroneIBA 05/2021
1	Gemcitabine FDA Link 01/2021
1	IronIBA 01/2021
1	Axitinib (AG 013736)IBA 01/2021
1	ImmunosorbentsIBA 01/2017
1	BradykininIBA 01/2017
1	Messenger RNA (mRNA)IBA 01/2017
1	LigandsIBA 01/2017
1	CC ChemokinesIBA 01/2017
1	Therapeutic UsesIBA 01/2016
1	Human Serum Albumin FDA LinkGeneric 01/2016
1	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 01/2016
1	NMDA receptor A1IBA 05/2015
1	Apolipoprotein E4IBA 05/2015
1	Indicators and Reagents (Reagents)IBA 05/2015
1	HLA-G Antigens (HLA G)IBA 03/2015
1	Fingolimod Hydrochloride (FTY720)FDA Link 09/2014
1	VanadiumIBA 07/2014
1	salicylhydroxamic acid (SHAM)IBA 01/2014
1	RNA (Ribonucleic Acid)IBA 01/2014
1	Sucrose (Saccharose)IBA 01/2014
1	KaolinIBA 09/2012
1	ChloridesIBA 04/2012
1	Evans Blue (Blue, Evans)FDA Link 04/2012
1	AntibodiesIBA 11/2010
1	amphiphysinIBA 11/2010
1	Immunoglobulin G (IgG)IBA 11/2010
1	Peptides (Polypeptides)IBA 08/2010
1	Neuroprotective AgentsIBA 10/2009
1	ParvalbuminsIBA 05/2009
1	Cyclic NucleotidesIBA 05/2009
1	Myelin ProteinsIBA 05/2009
1	gamma-Aminobutyric Acid (GABA)IBA 05/2009
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 05/2009
1	Kainic Acid (Kainate)IBA 04/2006
1	Glutamic Acid (Glutamate)FDA Link 04/2006
1	Dronabinol (THC)FDA LinkGeneric 10/2005
1	Estrogens (Estrogen)FDA Link 04/2005
1	Estrogen Receptor betaIBA 04/2005
1	Hormones (Hormone)IBA 12/2004
1	Glycophorins (Glycophorin C)IBA 10/2004

Therapy/Procedure

5	Therapeutics 05/2021 - 08/2002
1	Ligation 01/2014
1	Anesthesia 07/2013
1	Intraperitoneal Injections 05/2009